Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …

In this review we will describe eight commonly used rat brain tumor models and their
application for the development of novel therapeutic and diagnostic modalities. The C6, 9L …

Large doses of anticancer drugs entering cancer cell nuclei are found to be effective at
killing cancer cells and increasing chemotherapeutic effectiveness. Here we report red …

The cancer stem cell (CSC) model does not imply that tumours are generated from
transformed tissue stem cells. The target of transformation could be a tissue stem cell, a …

Background This study evaluated the safety and immune responses to an autologous
dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA) …

Purpose: Breast cancer stem cells have been shown to be associated with resistance to
chemotherapy in vitro, but their clinical significance remains to be clarified. The aim of this …

Introduction Whether cancer stem cells occur in BRCA1-associated breast cancer and
contribute to therapeutic response is not known. Methods We generated and characterized …

Hypoxia induces the expansion of glioblastoma stem cells (GSCs), but the mechanism
underlying it is still unclear. Here, we supply evidence that hypoxia-inducible factor-1α (HIF …

Conventional anticancer therapies, such as chemo-and/or radio-therapy are often unable to
completely eradicate cancers due to abnormal tumor microenvironment, as well as …

Cancer stem cells are a progressive concept to account for the cell biological nature of
cancer. Despite the controversies regarding the cancer stem cell model, it has the potential …