Nitric oxide has been known to play a significant role in the pathophysiology of various
disorders of the body. Despite its very short half-life, nitric oxide is known to modulate …

Affective disorders including major depressive disorder (MDD), bipolar disorder (BPD), and
general anxiety affect more than 10% of population in the world. Notably, neuronal nitric …

Abstract Hesperidin (4′-methoxy-7-O-rutinosyl-3′, 5-dihydroxyflavanone), a naturally
occurring flavanone glycoside, was previously shown to produce an antidepressant-like …

In order to improve the bioavailability of the antidepressant drug, venlafaxine hydrochloride,
in situ mucoadhesive thermoreversible gel, was formulated using Lutrol F127 (18%) as a …

Depression is associated with significant morbidity and functional disability, and it is thus
important to reveal the mechanism of depression. A variety of studies suggest an …

Inflammation, oxidative and nitrosative stress underlie depression being assessed in
rodents by the systemic administration of lipopolysacharide (LPS). There is an increasing …

The present study was undertaken to elucidate the alterations in various behavioral and
neurochemical basis of antidepressant action of bupropion [(±)-α-t-butylamino-3 …

In this study, the potential antidepressant-like effects of pioglitazone and the possible
involvement of peroxisome proliferator-activated receptor gamma (PPARγ) and nitric oxide …

The forced swim test (FST) and tail suspension test (TST) are widely used as animal models
for screening potential antidepressants. Immobility or despair behavior produced in both …

Venlafaxine (VLF) is an approved antidepressant that is claimed to have superior clinical
efficacy to comparable drugs. Recently, many studies showed the relationship between …