Vitamin B 6 is one of the most central molecules in cells of living organisms. It is a critical co-
factor for a diverse range of biochemical reactions that regulate basic cellular metabolism …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely
successful pathogen that adapts to survive within the host. During the latency phase of …

Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular
processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

To survive and proliferate in diverse host environments with varying nutrient availability, the
obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have …

Recent advances in liquid chromatography and mass spectrometry have enabled the highly
parallel, quantitative measurement of metabolites within a cell and the ability to trace their …

Multidrug resistance, strong side effects, and compliance problems in TB chemotherapy
mandate new ways to kill Mycobacterium tuberculosis (Mtb). Here we show that deletion of …

Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …

The composition of a cell in terms of macromolecular building blocks and other organic
molecules underlies the metabolic needs and capabilities of a species. Although some core …