Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Epidemiologic and clinical research has provided a large body of evidence supporting the
developmental origins of health and disease (DOHaD), but there has been a relative dearth …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …

This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …

ABSTRACT A vast array of successive epigenetic modifications ensures the creation of a
healthy individual. Crucial epigenetic reprogramming events occur during germ cell …

Although obesity, reduced physical activity, and aging increase susceptibility to type 2
diabetes, many people exposed to these risk factors do not develop the disease. Recent …

Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …

Epigenetic mechanisms are proposed as an important way in which the genome responds
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …