The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine
kinase, has served as a paradigm for successful application of molecularly targeted cancer …

Purpose With prospective clinical sequencing of tumors emerging as a mainstay in cancer
care, an urgent need exists for a clinical support tool that distills the clinical implications …

Proteins often undergo large conformational changes when binding small molecules, but
atomic-level descriptions of such events have been elusive. Here, we report unguided …

Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Purpose A dramatic improvement in the survival of patients with chronic myeloid leukemia
(CML) occurred after the introduction of imatinib mesylate, the first tyrosine kinase inhibitor …

PURPOSE Diffuse gliomas are malignant brain tumors that include lower-grade gliomas
(LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is …

Personalized medicine: Time for one-person trials | Nature Skip to main content Thank you for
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Anticancer drugs resistance is a complex process that arises from altering in the drug
targets. Advances in the DNA microarray, proteomics technology and the development of …