Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

JD Rudolf, CY Chang - Natural product reports, 2020 - pubs.rsc.org
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

C Ignea, MH Raadam, A Koutsaviti, Y Zhao… - Nature …, 2022 - nature.com
Humankind relies on specialized metabolites for medicines, flavors, fragrances, and
numerous other valuable biomaterials. However, the chemical space occupied by …

Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Expanding the structural diversity of terpenes by synthetic biology approaches

R Chen, M Wang, JD Keasling, T Hu, X Yin - Trends in Biotechnology, 2024 - cell.com
Terpenoids display chemical and structural diversities as well as important biological
activities. Despite their extreme variability, the range of these structures is limited by the …

Four billion years of microbial terpenome evolution

Y Hoshino, L Villanueva - FEMS microbiology reviews, 2023 - academic.oup.com
Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …

The hidden enzymology of bacterial natural product biosynthesis

TA Scott, J Piel - Nature Reviews Chemistry, 2019 - nature.com
Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli

MA Rinaldi, CA Ferraz, NS Scrutton - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2021 Terpenoids are a diverse group of chemicals used in a wide range of
industries. Microbial terpenoid production has the potential to displace traditional …

Enzymatic synthesis of methylated terpene analogues using the plasticity of bacterial terpene synthases

A Hou, L Lauterbach… - Chemistry–A European …, 2020 - Wiley Online Library
Methylated analogues of isopentenyl diphosphate were synthesised and enzymatically
incorporated into methylated terpenes. A detailed stereochemical analysis of the obtained …

Biosynthesis of the Non‐Canonical C17 Sesquiterpenoids Chlororaphen A and B from Pseudomonas Chlororaphis

H Xu, H Li, B Goldfuss, G Schnakenburg… - Angewandte Chemie …, 2024 - Wiley Online Library
Chlororaphens A and B are structurally unique non‐canonical C17 sesquiterpenoids from
Pseudomonas chlororaphis that are made by two SAM‐dependent methyltransferases and a …