Bacterial terpenome
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …
the structural diversity found in the superfamily of terpenoid natural products. These elegant …
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks
Humankind relies on specialized metabolites for medicines, flavors, fragrances, and
numerous other valuable biomaterials. However, the chemical space occupied by …
numerous other valuable biomaterials. However, the chemical space occupied by …
Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …
Expanding the structural diversity of terpenes by synthetic biology approaches
R Chen, M Wang, JD Keasling, T Hu, X Yin - Trends in Biotechnology, 2024 - cell.com
Terpenoids display chemical and structural diversities as well as important biological
activities. Despite their extreme variability, the range of these structures is limited by the …
activities. Despite their extreme variability, the range of these structures is limited by the …
Four billion years of microbial terpenome evolution
Y Hoshino, L Villanueva - FEMS microbiology reviews, 2023 - academic.oup.com
Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …
compounds in nature and are involved in many membrane-associated cellular processes …
The hidden enzymology of bacterial natural product biosynthesis
TA Scott, J Piel - Nature Reviews Chemistry, 2019 - nature.com
Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …
them with a remarkable range of biological activities that are of significant value to modern …
Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli
MA Rinaldi, CA Ferraz, NS Scrutton - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2021 Terpenoids are a diverse group of chemicals used in a wide range of
industries. Microbial terpenoid production has the potential to displace traditional …
industries. Microbial terpenoid production has the potential to displace traditional …
Enzymatic synthesis of methylated terpene analogues using the plasticity of bacterial terpene synthases
A Hou, L Lauterbach… - Chemistry–A European …, 2020 - Wiley Online Library
Methylated analogues of isopentenyl diphosphate were synthesised and enzymatically
incorporated into methylated terpenes. A detailed stereochemical analysis of the obtained …
incorporated into methylated terpenes. A detailed stereochemical analysis of the obtained …
Biosynthesis of the Non‐Canonical C17 Sesquiterpenoids Chlororaphen A and B from Pseudomonas Chlororaphis
Chlororaphens A and B are structurally unique non‐canonical C17 sesquiterpenoids from
Pseudomonas chlororaphis that are made by two SAM‐dependent methyltransferases and a …
Pseudomonas chlororaphis that are made by two SAM‐dependent methyltransferases and a …