Asymmetric allylic alkylation mediated by transition metals provides an efficient strategy to
form quaternary stereogenic centers. While this transformation is dominated by the use of …

A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

Metal-catalyzed reductive coupling has emerged as an alternative to the use of
stoichiometric organometallic reagents in an increasingly diverse range of carbonyl and …

Transformation of sterically hindered tertiary alkyl electrophiles under nickel-catalyzed
conditions to forge C (sp3)–C bonds and simultaneously create challenging all-carbon …

The asymmetric construction of all-carbon quaternary centres within acyclic settings
represents a long-standing challenge for synthetic chemists. Alongside polar and radical …

The asymmetric alkylation of enolates is a particularly versatile method for the construction
of α-stereogenic carbonyl motifs, which are ubiquitous in synthetic chemistry. Over the past …

Recent developments in the stereoselective synthesis of polysubstituted cyclopropanes
nowadays allow chemists to easily access these strained rings with high diastereo-and …

The cycloaddition reaction involving bicyclo [1.1. 0] butanes (BCBs) offers a versatile and
efficient synthetic platform for producing C (sp3)‐rich rigid bridged ring scaffolds, which act …

Dicarboxylic acids and derivatives are important building blocks in organic synthesis,
biochemistry, and the polymer industry. Although catalytic dicarboxylation with CO2 …

The unimolecular nucleophilic substitution (SN1) mechanism features prominently in every
introductory organic chemistry course. In principle, stepwise displacement of a leaving group …