Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Flavonoids are widely occurring secondary plant constituents, and are abundant in
vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for …

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

Chalcones constitute a group of phenolic compounds that command an increasing interest
on cancer research. Natural chalcones are widespread through the plant kingdom. The most …

Arylidene indanone (AI) scaffolds are considered as the rigid cousins of chalcones,
incorporating the α, β-unsaturated ketone system of chalcones forming a cyclic 5 membered …

The human P-glycoprotein (P-gp) efflux pump is of great interest for medicinal chemists
because of its important role in multidrug resistance (MDR). Because of the high …

Colon cancer poses a complex and substantial global health challenge, necessitating
innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse …