Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

The understanding that hyper-excitability and hyper-synchronism in epilepsy are
indissociably bound by a cause-consequence relation has only recently been challenged …

Bioelectronic medicine treats chronic diseases by sensing, processing, and modulating the
electronic signals produced in the nervous system of the human body, labeled'neural …

Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures which
in some conditions can develop into secondarily generalized tonic–clonic seizures by the …

Temporal-lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …

The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …

Based on the rationale that neural hypersynchronization underlies epileptic phenomena,
nonperiodic stimulation (NPS) was designed and successfully tested as an electrical …

Electrical stimulation of the central nervous system is a promising alternative for the
treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is …

Objectives Vagus nerve stimulation (VNS) has been widely used as an effective treatment
for patients with drug-resistant epilepsy (DRE). However, little is known about grey matter …

The understanding that hyper-excitability and hyper-synchronism in epilepsy are
indissociably bound by a cause-consequence relation has only recently been challenged …