Congenital adrenal hyperplasia—current insights in pathophysiology, diagnostics, and management
HL Claahsen-van der Grinten, PW Speiser… - Endocrine …, 2022 - academic.oup.com
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …
Basics of androgen synthesis and action
Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …
predominant androgen in males, while in adult females, T concentrations are about 15-fold …
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
WL Miller, RJ Auchus - Endocrine reviews, 2011 - academic.oup.com
Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …
Congenital adrenal hyperplasia
Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing
enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol …
enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol …
Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline
PW Speiser, R Azziz, LS Baskin… - The Journal of …, 2010 - academic.oup.com
Objective: We developed clinical practice guidelines for congenital adrenal hyperplasia
(CAH). Participants: The Task Force included a chair, selected by The Endocrine Society …
(CAH). Participants: The Task Force included a chair, selected by The Endocrine Society …
[HTML][HTML] Intracrine androgen biosynthesis, metabolism and action revisited
Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels
RS Swerdloff, RE Dudley, ST Page, C Wang… - Endocrine …, 2017 - academic.oup.com
Benefits associated with lowered serum DHT levels after 5 α-reductase inhibitor (5AR-I)
therapy in men have contributed to a misconception that circulating DHT levels are an …
therapy in men have contributed to a misconception that circulating DHT levels are an …
Adrenal cortex
PM Stewart - Current Opinion in Endocrinology, Diabetes and …, 1999 - journals.lww.com
Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …
function of the adrenal gland together with further insights into the physiologic and …
[HTML][HTML] Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid …
Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical
methods for steroid hormone analysis. It requires small sample volumes and has given rise …
methods for steroid hormone analysis. It requires small sample volumes and has given rise …
NADPH P450 oxidoreductase: structure, function, and pathology of diseases
Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …