[HTML][HTML] Searching for peripheral biomarkers in neurodegenerative diseases: the tryptophan-kynurenine metabolic pathway
Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …
which develops into a certain clinical picture. The pathogenesis and disease course vary …
[HTML][HTML] Tryptophan metabolism in central nervous system diseases: pathophysiology and potential therapeutic strategies
Y Huang, M Zhao, X Chen, R Zhang, A Le… - Aging and …, 2023 - ncbi.nlm.nih.gov
The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …
function. Altered TRP metabolism has been implicated in the pathophysiology of various …
Ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionization quantification of tryptophan metabolites and markers of gut …
A targeted ultrahigh-performance liquid chromatography tandem mass spectrometry with
electrospray ionization (UHPLC-ESI-MS/MS) method has been developed for the …
electrospray ionization (UHPLC-ESI-MS/MS) method has been developed for the …
[HTML][HTML] Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals …
Background Both serotonergic signalling disruption and systemic inflammation have been
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau
KR Jacobs, CK Lim, K Blennow, H Zetterberg… - Neurobiology of …, 2019 - Elsevier
Chronic kynurenine pathway (KP) activation is implicated in Alzheimer's disease (AD)
pathophysiology and results in quinolinic acid–induced excitotoxic stimulation of the N …
pathophysiology and results in quinolinic acid–induced excitotoxic stimulation of the N …
[HTML][HTML] Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and …
Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …
[HTML][HTML] Nutritional therapy to modulate tryptophan metabolism and aryl hydrocarbon-receptor signaling activation in human diseases
M Ghiboub, CM Verburgt, B Sovran, MA Benninga… - Nutrients, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a nuclear protein which, upon association with
certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and …
certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and …
[HTML][HTML] Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder
M Sakurai, Y Yamamoto, N Kanayama, M Hasegawa… - Scientific reports, 2020 - nature.com
Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-
kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this …
kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this …
Kynurenine metabolism and alzheimer's disease: the potential targets and approaches
Abstract l-tryptophan, an essential amino acid, regulates protein homeostasis and plays a
role in neurotransmitter-mediated physiological events. It also influences age-associated …
role in neurotransmitter-mediated physiological events. It also influences age-associated …
[HTML][HTML] Kynurenine pathway metabolites as biomarkers for amyotrophic lateral sclerosis
VX Tan, GJ Guillemin - Frontiers in Neuroscience, 2019 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) currently lacks a robust and well-defined biomarker that
can 1) assess the progression of the disease, 2) predict and/or delineate the various clinical …
can 1) assess the progression of the disease, 2) predict and/or delineate the various clinical …