Optical microscopy has been a fundamental tool of biological discovery for more than three
centuries, but its in vivo tissue imaging ability has been restricted by light scattering to …

Optical imaging is a powerful modality in biological discovery. The mainstream of optical
interrogations, however, largely relies on microscopy, which imposes depth limitations on …

Fluorescence sampling of cellular function is widely used in all aspects of biology, allowing
the visualization of cellular and sub-cellular biological processes with spatial resolutions in …

The development of hybrid optical tomography methods to improve imaging performance
has been suggested over a decade ago and has been experimentally demonstrated in …

Emerging fluorescence and bioluminescence tomography approaches have several
common, yet several distinct features from established emission tomographies of PET and …

Multimodal approaches that combine near-infrared (NIR) and conventional imaging
modalities have been shown to improve optical parameter estimation dramatically and thus …

Fluorescence microscopic imaging is widely used in biomedical research to study molecular
and cellular processes in cell culture or tissue samples. This is motivated by the high …

The invention relates to a combined x-ray and optical (light-based) tomographic imaging
system that provides functional information at greater resolution than can be achieved by …

A hybrid imaging system for simultaneous fluorescence tomography and X-ray computed
tomography (XCT) of small animals has been developed and presented. The system …

The development of methods to accurately quantify cell-surface receptors in living tissues
would have a seminal impact in oncology. For example, accurate measures of receptor …