Protective fibroblastic niches in secondary lymphoid organs
A De Martin, Y Stanossek, NB Pikor… - Journal of Experimental …, 2024 - rupress.org
Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
[HTML][HTML] Insights into CSF-1R expression in the tumor microenvironment
C Tomassetti, G Insinga, F Gimigliano, A Morrione… - Biomedicines, 2024 - mdpi.com
The colony-stimulating factor 1 receptor (CSF-1R) plays a pivotal role in orchestrating
cellular interactions within the tumor microenvironment (TME). Although the CSF-1R has …
cellular interactions within the tumor microenvironment (TME). Although the CSF-1R has …
[HTML][HTML] Tissue fibroblasts are versatile immune regulators: an evaluation of their impact on the aging process
A Salminen, K Kaarniranta, A Kauppinen - Ageing Research Reviews, 2024 - Elsevier
Fibroblasts are abundant stromal cells which not only control the integrity of extracellular
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …
Neu1 deficiency and fibrotic lymph node microenvironment lead to imbalance in M1/M2 macrophage polarization
E Escalona, A Olate-Briones… - Frontiers in …, 2024 - frontiersin.org
Macrophages play a pivotal role in tissue homeostasis, pathogen defense, and inflammation
resolution. M1 and M2 macrophage phenotypes represent two faces in a spectrum of …
resolution. M1 and M2 macrophage phenotypes represent two faces in a spectrum of …
On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking
The lymph node paracortex, also known as the T-cell zone, consists of a network of
fibroblastic reticular cells (FRCs) that secrete chemokines to induce T-cell and dendritic cell …
fibroblastic reticular cells (FRCs) that secrete chemokines to induce T-cell and dendritic cell …
Subcutaneous delivery of mesenchymal stromal cells induces immunoregulatory effects in the lymph node prior to their apoptosis
Background Mesenchymal stromal cell (MSC) therapy commonly involves systemic infusion
of MSCs, which undergo apoptosis in the lung and induce immunoregulatory macrophages …
of MSCs, which undergo apoptosis in the lung and induce immunoregulatory macrophages …
An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases
Y Xu, Z Wang, S Li, J Su, L Gao, J Ou, Z Lin… - Science China Life …, 2024 - Springer
T cells play a critical and irreplaceable role in maintaining overall health. However, their
functions undergo alterations as individuals age. It is of utmost importance to comprehend …
functions undergo alterations as individuals age. It is of utmost importance to comprehend …
Role of estrogen signaling in fibroblastic reticular cells for innate and adaptive immune responses in antigen‐induced arthritis
A Barrett, K Horkeby, C Corciulo… - … and Cell Biology, 2024 - Wiley Online Library
Women are more prone to develop rheumatoid arthritis, with peak incidence occurring
around menopause. Estrogen has major effects on the immune system and is protective …
around menopause. Estrogen has major effects on the immune system and is protective …
[HTML][HTML] Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development
AMS Barron, T Fabre, S De - F1000Research, 2024 - ncbi.nlm.nih.gov
Fibroblasts are ubiquitous cells that can adopt many functional states. As tissue-resident
sentinels, they respond to acute damage signals and shape the earliest events in fibrotic …
sentinels, they respond to acute damage signals and shape the earliest events in fibrotic …
Enter the Matrix: Fibroblast-immune interactions shape ECM deposition in health and disease.
A Altieri, GV Visser, MB Buechler - F1000Research, 2024 - f1000research.com
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which
regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic …
regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic …