The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Type I interferons (IFNs) play a crucial role in the innate immune avant-garde against viral
infections. Virtually all viruses have developed means to counteract the induction, signaling …

RNA silencing or interference (RNAi) is a gene regulation mechanism in eukaryotes that
controls cell differentiation and developmental processes via expression of microRNAs …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta
interferon (IFN-α/β)-and IFN-γ-induced nuclear accumulation of tyrosine-phosphorylated …

Abstract Ebola viral protein 35 (VP35), encoded by the highly pathogenic Ebola virus,
facilitates host immune evasion by antagonizing antiviral signaling pathways, including …

The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented
negative-sense RNA viruses of the order Mononegavirales. The mode of replication and …

The Ebola virus and its close relative, the Marburg virus, both belong to the family Filoviridae
and are highly hazardous and contagious viruses. With a mortality rate ranging from 23% to …

Mechanisms by which viruses counter innate host defense responses generally involve
inhibition of one or more components of the interferon (IFN) system. Multiple steps in the …