[HTML][HTML] Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
[HTML][HTML] The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …
epigenetic information. In yeast, epigenetic information is lost over time due to the …
[HTML][HTML] Hallmarks of health
C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …
as a compendium of organizational and dynamic features that maintain physiology. The …
[HTML][HTML] Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …
General perceptions and experimental evidence pinpoint that the decline of physical …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination
Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …
The epigenetic basis of cellular heterogeneity
Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …
substantial heterogeneity in expression levels among morphologically indistinguishable …
The ageing epigenome and its rejuvenation
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …