Antimicrobial peptides: an update on classifications and databases
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …
indispensable component of host defenses. They consist of predominantly short cationic …
Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Peptide design principles for antimicrobial applications
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …
global health problem and highlights the need for novel anti-infective therapies …
Membrane active antimicrobial peptides: translating mechanistic insights to design
J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …
[HTML][HTML] Cell-penetrating peptides: 20 years later, where do we stand?
Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …
novel field in molecular delivery based on these non-invasive vectors, most commonly …
Membrane active peptides and their biophysical characterization
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …
active peptides. These peptides exert their biological activity by interacting with the cell …
[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
plays an indispensible role in human health. While there are multiple copies of cathelicidin …
Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis
The synthetic cyclic hexapeptide cWFW (cyclo (RRRWFW)) has a rapid bactericidal activity
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …
against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has …
Selectivity and mechanism of fengycin, an antimicrobial lipopeptide, from molecular dynamics
S Sur, TD Romo, A Grossfield - The Journal of Physical Chemistry …, 2018 - ACS Publications
Fengycin is a cyclic lipopeptide used as an agricultural fungicide. It is synthesized by
Bacillus subtilis as an immune response against fungal infection and functions by damaging …
Bacillus subtilis as an immune response against fungal infection and functions by damaging …
[HTML][HTML] Peptide: lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional …
MC Manzini, KR Perez, KA Riske, JC Bozelli Jr… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The cecropin-melittin hybrid antimicrobial peptide BP100 (H-KKLFKKILKYL-NH2) is
selective for Gram-negative bacteria, negatively charged membranes, and weakly hemolytic …
selective for Gram-negative bacteria, negatively charged membranes, and weakly hemolytic …