Zinc coordination sphere in biochemical zinc sites
DS Auld - Zinc biochemistry, physiology, and homeostasis: recent …, 2001 - Springer
Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …
Snake venom metalloproteinases
FS Markland Jr, S Swenson - Toxicon, 2013 - Elsevier
Recent proteomic analyses of snake venoms show that metalloproteinases represent major
components in most of the Crotalid and Viperid venoms. In this chapter we discuss the …
components in most of the Crotalid and Viperid venoms. In this chapter we discuss the …
Automated protein model building combined with iterative structure refinement
A Perrakis, R Morris, VS Lamzin - Nature structural biology, 1999 - nature.com
In protein crystallography, much time and effort are often required to trace an initial model
from an interpretable electron density map and to refine it until it best agrees with the …
from an interpretable electron density map and to refine it until it best agrees with the …
The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function
Leishmania sp. are digenetic protozoa that cause an estimated 1.5–2 million new cases of
leishmaniasis per year worldwide. Among the molecular factors that contribute to …
leishmaniasis per year worldwide. Among the molecular factors that contribute to …
Structural aspects of the metzincin clan of metalloendopeptidases
FX Gomis-Rüth - Molecular biotechnology, 2003 - Springer
Metalloendopeptidases are present across all kingdoms of living organisms; they are
ubiquitous and widely involved in metabolism regulation through their ability either to …
ubiquitous and widely involved in metabolism regulation through their ability either to …
Catalytic domain architecture of metzincin metalloproteases
FX Gomis-Rüth - Journal of biological chemistry, 2009 - ASBMB
Metalloproteases cleave proteins and peptides, and deregulation of their function leads to
pathology. An understanding of their structure and mechanisms of action is necessary to the …
pathology. An understanding of their structure and mechanisms of action is necessary to the …
Architecture and function of metallopeptidase catalytic domains
N Cerdà‐Costa, F Xavier Gomis‐Rüth - Protein Science, 2014 - Wiley Online Library
The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These
ubiquitous enzymes participate in all major physiological processes, and so their …
ubiquitous enzymes participate in all major physiological processes, and so their …
Biological roles of proteases in parasitic protozoa
M Klemba, DE Goldberg - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Proteases from a variety of protozoan parasites have been characterized at the
molecular and cellular levels, and the many roles that proteases play in these organisms are …
molecular and cellular levels, and the many roles that proteases play in these organisms are …
Cell biology of Leishmania
E Handman - Advances in parasitology, 1999 - Elsevier
Leishmania are digenetic protozoa which inhabit two highly specific hosts, the sandfly,
where they grow as motile flagellated promastigotes in the gut, and the mammalian …
where they grow as motile flagellated promastigotes in the gut, and the mammalian …
Proteinases as virulence factors in Leishmania spp. infection in mammals
M Silva-Almeida, BAS Pereira… - Parasites & vectors, 2012 - Springer
Leishmania parasites cause human tegumentary and visceral infections that are commonly
referred to as leishmaniasis. Despite the high incidence and prevalence of cases …
referred to as leishmaniasis. Despite the high incidence and prevalence of cases …