Zinc is known to be indispensable to growth and development and transmission of the
genetic message. It does this through a remarkable mosaic of zinc binding motifs that …

Recent proteomic analyses of snake venoms show that metalloproteinases represent major
components in most of the Crotalid and Viperid venoms. In this chapter we discuss the …

In protein crystallography, much time and effort are often required to trace an initial model
from an interpretable electron density map and to refine it until it best agrees with the …

Leishmania sp. are digenetic protozoa that cause an estimated 1.5–2 million new cases of
leishmaniasis per year worldwide. Among the molecular factors that contribute to …

Metalloendopeptidases are present across all kingdoms of living organisms; they are
ubiquitous and widely involved in metabolism regulation through their ability either to …

Metalloproteases cleave proteins and peptides, and deregulation of their function leads to
pathology. An understanding of their structure and mechanisms of action is necessary to the …

The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These
ubiquitous enzymes participate in all major physiological processes, and so their …

▪ Abstract Proteases from a variety of protozoan parasites have been characterized at the
molecular and cellular levels, and the many roles that proteases play in these organisms are …

Leishmania are digenetic protozoa which inhabit two highly specific hosts, the sandfly,
where they grow as motile flagellated promastigotes in the gut, and the mammalian …

Leishmania parasites cause human tegumentary and visceral infections that are commonly
referred to as leishmaniasis. Despite the high incidence and prevalence of cases …