Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …

Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

The two major lineages of classical dendritic cells (cDCs) express and require either IRF8 or
IRF4 transcription factors for their development and function. IRF8-dependent cDCs promote …

Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-
associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through …

Many parasitic worms possess complex and intriguing life cycles, and schistosomes are no
exception. To exit the human body and progress to their successive snail host, Schistosoma …

Signalling C‐type lectin receptors (CLR s) are crucial in shaping the immune response to
fungal pathogens, but comparably little is known about the role of these receptors in …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

There is a wealth of immunologic studies that have been carried out in experimental and
human schistosomiasis that can be classified into three main areas: immunopathogenesis …