Polyamines (PAs) are essential organic polycations for cell viability along the whole
phylogenetic scale. In mammals, they are involved in the most important physiological …

Polyamines are polycationic organic amines that are required for all eukaryotic life,
exemplified by the polyamine spermidine, which plays an essential role in translation. They …

Abstract Fisetin, quercetin, luteolin and 7, 8-hydroxyflavone show high activity in Leishmania
cultures and present low toxicity to mammalian cells. In this work, the structural aspects of 13 …

Epigallocatechin-3-gallate (EGCG), a dietary polyphenol (flavanol) from green tea,
possesses leishmanicidal and antitrypanosomal activity. Mitochondrial damage was …

The plant Cecropia pachystachya Trécul is widely used in Brazilian ethnomedicine to treat
hypertension, asthma, and diabetes. Arginase is an enzyme with levels that are elevated in …

Arginase, the binuclear metalloenzyme, is a potential target for therapeutic intervention in
protozoan infections. Entamoeba histolytica infection causes amebiasis which is the second …

Members of Myxozoa, a parasitic metazoan taxon, have considerable detrimental effects on
fish hosts and also have been associated with human food-borne illness. Little is known …

All living organisms depend on NADPH production to feed essential biosyntheses and for
oxidative stress defense. Protozoan parasites such as the sleeping sickness pathogen …

Histamine, serotonin and dopamine are biogenic amines involved in intercellular
communication with multiple effects on human pathophysiology. They are products of two …

Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that
affects about 6 million people in Latin America. Despite its sanitary importance, there are …