Secretion systems in Gram-negative bacteria: structural and mechanistic insights

TRD Costa, C Felisberto-Rodrigues, A Meir… - Nature Reviews …, 2015 - nature.com
Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

Aim, load, fire: the type VI secretion system, a bacterial nanoweapon

FR Cianfanelli, L Monlezun, SJ Coulthurst - Trends in microbiology, 2016 - cell.com
Bacteria utilise specialised protein secretion systems to interact with host organisms,
competitor bacteria, and the environment. The Type VI secretion system (T6SS) is a versatile …

Type VI secretion system effectors: poisons with a purpose

AB Russell, SB Peterson, JD Mougous - Nature reviews microbiology, 2014 - nature.com
The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-
negative bacterial species. Recent studies have led to a substantial increase in the number …

A view to a kill: the bacterial type VI secretion system

BT Ho, TG Dong, JJ Mekalanos - Cell host & microbe, 2014 - cell.com
The bacterial type VI secretion system (T6SS) is an organelle that is structurally and
mechanistically analogous to an intracellular membrane-attached contractile phage tail …

Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

TG Sana, N Flaugnatti, KA Lugo… - Proceedings of the …, 2016 - National Acad Sciences
The mammalian gastrointestinal tract is colonized by a high-density polymicrobial
community where bacteria compete for niches and resources. One key competition strategy …

Type VI secretion system effector proteins: effective weapons for bacterial competitiveness

RE Hernandez, R Gallegos‐Monterrosa… - Cellular …, 2020 - Wiley Online Library
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread
among Gram‐negative bacteria and used as a means to deliver effectors directly into target …

Activity, delivery, and diversity of Type VI secretion effectors

D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …

The Pseudomonas putida T6SS is a plant warden against phytopathogens

P Bernal, LP Allsopp, A Filloux, MA Llamas - The ISME journal, 2017 - academic.oup.com
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver
toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial …

Structure of the T4 baseplate and its function in triggering sheath contraction

NMI Taylor, NS Prokhorov, RC Guerrero-Ferreira… - Nature, 2016 - nature.com
Several systems, including contractile tail bacteriophages, the type VI secretion system and
R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell …