Over the past forty years, animal models of focal cerebral ischaemia have allowed us to
identify the critical cerebral blood flow thresholds responsible for irreversible cell death …

Circulating thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator
inhibitor-1 (PAI-1) are causal factors for thrombolytic failure. Therefore, we evaluated an …

Background and Purpose—The debate over the fact that experimental drugs proposed for
the treatment of stroke fail in the translation to the clinical situation has attracted …

Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a major contributor to
physiological and pathological glutamate-mediated Ca2+ signals, and its involvement in …

Ischemic stroke occurs abruptly causing sudden neurologic deficits, and therefore, very little
is known about hemodynamic perturbations in the brain immediately after stroke onset …

Background Laser Doppler flowmetry (LDF) can reliably reflect brain perfusion in
experimental stroke by monitoring both the degree and the duration of relative regional …

The treatment of acute ischemic stroke (AIS) using thrombolysis with recombinant tissue-
plasminogen activator (rtPA, alteplase) is limited by its narrow time window and the risk of …

Background: Since thrombolysis is the only approved intervention for ischemic stroke,
improving its efficacy and safety is a therapeutic aim of considerable interest. The activated …

We used a new multimodal imaging system that combines optical coherence microscopy
and brightfield microscopy. Using this in vivo brain monitoring approach and cranial window …

Stroke is a leading cause of death worldwide [1], and is the third leading cause of death and
the leading cause of serious adult disability in New Zealand [2]. The aim of this project was …