Speciation results from the progressive accumulation of mutations that decrease the
probability of mating between parental populations or reduce the fitness of hybrids—the so …

Interactions between alleles and across environments play an important role in the fitness of
hybrids and are at the heart of the speciation process. Fitness landscapes capture these …

Understanding general principles about the origin of species remains one of the
foundational challenges in evolutionary biology. The genomic divergence between groups …

Theory building is an integral part of biological research, in general, and of speciation
research, in particular. Here, I review the modeling work on speciation done in the last 10 …

Structured populations, and replicated zones of contact between species, are an ideal
opportunity to study regions of the genome with unusual levels of differentiation; and these …

Patterns of amino acid conservation have served as a tool for understanding protein
evolution. The same principles have also found broad application in human genomics …

Natural selection plays a variety of roles in hybridization, speciation, and admixture. Most
research has focused on two extreme cases: crosses between closely related inbred lines …

Research in speciation genetics has uncovered many robust patterns in intrinsic
reproductive isolation, and fitness landscape models have been useful in interpreting these …

Interspecific crossing experiments have shown that sex chromosomes play a major role in
reproductive isolation between many pairs of species. However, their ability to act as …

Reproductive isolation can rise either as a consequence of genomic divergence in allopatry
or as a byproduct of divergent selection in parapatry. To determine whether reproductive …