A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Recent advances in microfluidic technology for bioanalysis and diagnostics

SF Berlanda, M Breitfeld, CL Dietsche… - Analytical …, 2020 - ACS Publications
Microfluidics has become a mature technology, providing an excellent toolbox for the
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …

Microfluidic organ-on-a-chip: a guide to biomaterial choice and fabrication

UMN Cao, Y Zhang, J Chen, D Sayson, S Pillai… - International journal of …, 2023 - mdpi.com
Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis

J Ko, J Ahn, S Kim, Y Lee, J Lee, D Park, NL Jeon - Lab on a Chip, 2019 - pubs.rsc.org
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …

3D bioprinted organ‐on‐chips

S Rahmani Dabbagh, M Rezapour Sarabi… - …, 2023 - Wiley Online Library
Abstract Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more
realistically compared to many animal models and conventional two‐dimensional cell …

Design and fabrication of organ-on-chips: promises and challenges

A Tajeddin, N Mustafaoglu - Micromachines, 2021 - mdpi.com
The advent of the miniaturization approach has influenced the research trends in almost all
disciplines. Bioengineering is one of the fields benefiting from the new possibilities of …

Open microfluidic capillary systems

E Berthier, AM Dostie, UN Lee, J Berthier… - Analytical …, 2019 - ACS Publications
Open microfluidic capillary systems are a rapidly evolving branch of microfluidics where
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …

Piezo1-regulated mechanotransduction controls flow-activated lymphatic expansion

D Choi, E Park, RP Yu, MN Cooper, IT Cho… - Circulation …, 2022 - Am Heart Assoc
Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1)
cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI …

Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts

S Lee, H Kim, BS Kim, S Chae, S Jung, JS Lee… - Nature …, 2024 - nature.com
Several functions of autophagy associated with proliferation, differentiation, and migration of
endothelial cells have been reported. Due to lack of models recapitulating angiogenic …

Injection molding and characterization of PMMA-based microfluidic devices

X Ma, R Li, Z Jin, Y Fan, X Zhou, Y Zhang - Microsystem Technologies, 2020 - Springer
Microfluidics has been widely used in biological, chemical, medical and environmental fields
for the precise control of liquid in micro/nanoscale. Various fabrication methods have been …