Advances in the development of new biomarkers for Alzheimer's disease
TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …
The role of microRNAs in neurodegenerative diseases: a review
S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …
regulators in various neuronal degenerative diseases and playact a key role in these …
BACE1: More than just a β‐secretase
HA Taylor, L Przemylska, EM Clavane… - Obesity …, 2022 - Wiley Online Library
Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …
historically focused on its actions as the β‐secretase responsible for the production of β …
MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …
neuronal and non-neuronal cell functions and play a key role in pathological conditions …
The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
Current status of microRNA-based therapeutic approaches in neurodegenerative disorders
S Paul, LA Bravo Vázquez, S Pérez Uribe… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are a key gene regulator and play essential roles in several biological
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
and pathological mechanisms in the human system. In recent years, plenty of miRNAs have …
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease
F Zhang, R Zhong, C Cheng, S Li, W Le - Acta Pharmacologica Sinica, 2021 - nature.com
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative
disease in elderly people, will impose social and economic burdens to the world. Currently …
disease in elderly people, will impose social and economic burdens to the world. Currently …
Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
W Grabowska-Pyrzewicz, A Want, J Leszek… - EBioMedicine, 2021 - thelancet.com
Alzheimer's disease (AD) represents a particular therapeutic challenge because its
aetiology is very complex, with dynamic progression from preclinical to clinical stages …
aetiology is very complex, with dynamic progression from preclinical to clinical stages …
TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease
S Zhang, F Cao, W Li, N Abumaria - Science signaling, 2023 - science.org
Altered abundance or activity of the dual-function transient receptor potential melastatin-like
7 (TRPM7) protein is implicated in neurodegenerative disorders, including Alzheimer's …
7 (TRPM7) protein is implicated in neurodegenerative disorders, including Alzheimer's …
Delivering the promise of gene therapy with nanomedicines in treating central nervous system diseases
Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …