The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

RNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of
dysregulated splicing in hematopoiesis remains unclear. To overcome technical limitations …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …

Transcription and splicing of pre-messenger RNA are closely coordinated, but how this
functional coupling is disrupted in human diseases remains unexplored. Using isogenic cell …

RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …

Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a
favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 …

Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid
cancers and result in widespread alterations in splicing, yet there is currently no therapeutic …