HDACs and HDAC inhibitors in cancer development and therapy

Y Li, E Seto - Cold Spring Harbor perspectives in …, 2016 - perspectivesinmedicine.cshlp.org
Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective

ML Jin, KW Jeong - Experimental & Molecular Medicine, 2023 - nature.com
The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

Parthenolide promotes the repair of spinal cord injury by modulating M1/M2 polarization via the NF-κB and STAT 1/3 signaling pathway

T Gaojian, Q Dingfei, L Linwei, W Xiaowei… - Cell death …, 2020 - nature.com
Spinal cord injury (SCI) is a severe neurological disease; however, there is no effective
treatment for spinal cord injury. Neuroinflammation involves the activation of resident …

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

R Camicia, HC Winkler, PO Hassa - Molecular cancer, 2015 - Springer
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

Targeting histone deacetylases in idiopathic pulmonary fibrosis: a future therapeutic option

M Korfei, P Mahavadi, A Guenther - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Histone deacetylases as targets for treatment of multiple diseases

J Tang, H Yan, S Zhuang - Clinical science, 2013 - portlandpress.com
HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

STAT3 interactors as potential therapeutic targets for cancer treatment

F Laudisi, F Cherubini, G Monteleone… - International journal of …, 2018 - mdpi.com
Signal transducers and activators of transcription (STATs) mediate essential signaling
pathways in different biological processes, including immune responses, hematopoiesis …

Regulation of STAT signaling by acetylation

S Zhuang - Cellular signalling, 2013 - Elsevier
Signal transducers and activators of transcription (STAT) belong to a family of latent
cytoplasmic factors that can be activated by tyrosine phosphorylation by the members of the …

Ketogenic diet elicits antitumor properties through inducing oxidative stress, inhibiting MMP-9 expression, and rebalancing M1/M2 tumor-associated macrophage …

N Zhang, C Liu, L Jin, R Zhang, T Wang… - Journal of agricultural …, 2020 - ACS Publications
Many advanced cancers are characterized by metabolic disorders. A dietary therapeutic
strategy was proposed to inhibit tumor growth through administration of low-carbohydrate …

Feedback activation of leukemia inhibitory factor receptor limits response to histone deacetylase inhibitors in breast cancer

H Zeng, J Qu, N Jin, J Xu, C Lin, Y Chen, X Yang, X He… - Cancer cell, 2016 - cell.com
Histone deacetylase (HDAC) inhibitors have demonstrated clinical benefits in subtypes of
hematological malignancies. However, the efficacy of HDAC inhibitors in solid tumors …