Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Abstract Purpose of Review In recent years, the role of the gastrointestinal (GI) tract in
energy homeostasis through modulation of the digestion and absorption of carbohydrates …

A large body of literature documents the occurrence of alterations in the physiology of both
central and peripheral modulators of appetite in acute patients with anorexia nervosa (AN) …

G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They
initiate these actions by being activated by a wide variety of natural ligands. Historically …

OBJECTIVE—Obestatin is a newly discovered peptide encoded by the ghrelin gene whose
biological functions are poorly understood. We investigated obestatin effect on survival of β …

In mammals, ghrelin is a non-amidated peptide hormone, existing in both acylated and non-
acylated forms, produced mainly from the X/A or ghrelin cells present in the mucosal layer of …

The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3
position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of …

In this sweeping exploration of the relatively recent obesity epidemic, Michael L. Power and
Jay Schulkin probe evolutionary biology, history, physiology, and medical science to …

Obesity is a complex, multifactorial disease that is a major public health issue worldwide.
Currently approved anti-obesity medications and lifestyle interventions lack the efficacy and …

Numerous peptides released from endocrine cells in the intestinal mucosa were established
early on to be involved in the physiological regulation of food intake with a prominent role in …