Chronic lymphocytic leukaemia: from genetics to treatment
F Bosch, R Dalla-Favera - Nature reviews Clinical oncology, 2019 - nature.com
Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
BIRC3 and BIRC5: multi‐faceted inhibitors in cancer
R Frazzi - Cell & bioscience, 2021 - Springer
Background The evasion from apoptosis is a common strategy adopted by most tumors, and
inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and …
inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and …
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …
determining the clinicobiological behaviour are not fully understood. Here we describe a …
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic
leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to …
leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to …
The molecular pathogenesis of chronic lymphocytic leukaemia
G Fabbri, R Dalla-Favera - Nature Reviews Cancer, 2016 - nature.com
Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
S Beà, R Valdés-Mas, A Navarro… - Proceedings of the …, 2013 - National Acad Sciences
Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an
indolent clinical course. To understand the mechanisms underlying this biological …
indolent clinical course. To understand the mechanisms underlying this biological …
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
R Rathore, JE McCallum, E Varghese, AM Florea… - Apoptosis, 2017 - Springer
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …
Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL
In the phase 3 RESONATE study, ibrutinib demonstrated superior progression-free survival
(PFS), overall survival (OS) and overall response rate (ORR) compared with ofatumumab in …
(PFS), overall survival (OS) and overall response rate (ORR) compared with ofatumumab in …
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
The identification of new genetic lesions in chronic lymphocytic leukemia (CLL) prompts a
comprehensive and dynamic prognostic algorithm including gene mutations and …
comprehensive and dynamic prognostic algorithm including gene mutations and …
[HTML][HTML] Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
E Ten Hacken, JA Burger - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …
which are highly dependent on interactions with the tissue microenvironment for their …