Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Background The evasion from apoptosis is a common strategy adopted by most tumors, and
inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and …

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic
leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an
indolent clinical course. To understand the mechanisms underlying this biological …

Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …

In the phase 3 RESONATE study, ibrutinib demonstrated superior progression-free survival
(PFS), overall survival (OS) and overall response rate (ORR) compared with ofatumumab in …

The identification of new genetic lesions in chronic lymphocytic leukemia (CLL) prompts a
comprehensive and dynamic prognostic algorithm including gene mutations and …

Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …