Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

Research in recent years has focused significantly on the role of selective macroautophagy
in targeting intracellular pathogens for lysosomal degradation, a process termed xenophagy …

Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

INTRODUCTION Lysosomes are degradative organelles that break down diverse materials
delivered from inside and outside the cell by specialized vesicles called endosomes …

Selective macroautophagy (hereafter referred to as autophagy) describes a process in
which cytosolic material is engulfed in a double membrane organelle called an …

Cells respond to endolysosome damage by either repairing the damage or targeting
damaged endolysosomes for degradation via lysophagy. However, the signals regulating …

Autophagy is a cellular innate-immune defence mechanism against intracellular
microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non …

Inflammasomes can prevent systemic dissemination of enteropathogenic bacteria. As
adapted pathogens including Salmonella Typhimurium (S. Tm) have evolved evasion …

The delivery of pathogens to lysosomes for degradation provides an important defense
against infection. Degradation is enhanced when LC3 is conjugated to endosomes and …

Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once
endocytosed, these reagents must overcome endosomal entrapment to ensure the release …