Retinitis pigmentosa is a retinal degeneration transmitted by varied modes of inheritance
and affects approximately 1 in 4000 individuals. The photoreceptors of the outer retina, as …

Posttranslational modifications (PTMs) are known to constitute a key step in protein
biosynthesis and in the regulation of protein functions. Recent breakthroughs in protein …

The heterologous expression of membrane proteins such as G protein-coupled receptors
can be a notoriously difficult task. We have engineered an expression vector, p1D4-hrGFP II …

NCS1 (neuronal calcium sensor-1) is a Ca2+-myristoyl switch protein of the NCS protein
family involved in synaptic plasticity and neurotransmission via Ca2+-dependent regulation …

Rod cell membranes contain cholesterol-rich detergent-resistant membrane (DRM) rafts,
which accumulate visual cascade proteins as well as proteins involved in regulation of …

The cytoplasmic sides of transmembrane helices 3 and 6 of G-protein-coupled receptors are
connected by a network of ionic interactions that play an important role in maintaining its …

Abstract Antibodies AB 60–72 and AB 80–92 against two immune-dominant epitopes of
photoreceptor Ca 2+-binding protein recoverin, 60-DPKAYAQHVFRSF-72 and 80 …

Neuronal responses to Ca 2+-signals are provided by EF-hand-type neuronal Ca 2+-sensor
(NCS) proteins, which have similar core domains containing Ca 2+-binding and target …

It was previously shown that opsin can be regenerated with the newly synthesized 11‐cis‐7‐
methyl‐retinal forming an artificial visual pigment. We now extend this study to include …

Recoverin is a Ca 2+-binding protein implicated in the Ca 2+-dependent regulation of
desensitization of visual receptor rhodopsin in vertebrate retinal rods. Here we report that Ca …