This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Small arteries exhibit tone, a partially contracted state that is an important determinant of
blood pressure. In arterial smooth muscle cells, intracellular calcium paradoxically controls …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

Vasodilatory factors produced by the endothelium are critical for the maintenance of normal
blood pressure and flow. We hypothesized that endothelial signals are transduced to …

The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular
dementia is increasingly viewed as a therapeutic target for disease-modifying therapy …

Changes in intracellular Ca2+ are central to the function of smooth muscle, which lines the
walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide …