There is evidence that there is a bidirectional relationship between major depression and
cardiovascular disorder (CVD): depressed patients are a population at risk for increased …

Cardiovascular diseases (CVD) remain the major cause of morbidity and mortality in
Europe. The clinical complications associated to arterial wall rupture involve intimal cap …

Background: Obesity plays crucial roles in the development of cardiovascular diseases.
However, the mechanisms that link obesity and cardiovascular diseases remain elusive …

The role of adaptive immunity in contributing to post-traumatic neuroinflammation and
neuropathology after head injury remains largely unexplored. The present study was …

Objective Aging is associated with compromised immune function and arterial remodeling
and stiffness. The purpose of this study is to investigate whether in vivo AAV-based delivery …

This review aimed to capture the key findings that animal models have provided around the
role of the alternative pathway and amplification loop (AP/AL) in disease. Animal models …

OBJECTIVE: Gamma-globulin treatment reduces experimental atherosclerosis by
modulating immune function; however the effect of IgM on atherosclerosis is not known. We …

Percutaneous coronary intervention is widely adopted to treat patients with coronary artery
disease. However, restenosis remains an unsolved clinical problem after vascular …

Suppressor of cytokine signaling (SOCS) proteins are inducible feedback inhibitors of
cytokine signaling. SOCS1−/− mice die within three weeks postnatally due to IFN-γ-induced …

Natural antibodies (NAbs) play an important role in early host defense, autophagy and
tissue remodeling, and in immune regulation. They arise spontaneously (without specific …