Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages
JR Mark, A Titus, HR Staley, S Alvarez, S Mahn… - bioRxiv, 2024 - biorxiv.org
The motor stage of idiopathic Parkinson's disease (iPD) can be preceded for years by a
prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder …
prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder …
MHCII deletion in mouse myeloid cells alters T-cell subset frequencies and inflammatory responses to alpha-synuclein pathology and epigenetic analysis of human …
Major histocompatibility complex class II (MHCII) molecules are antigen presentation
proteins and increased in post-mortem Parkinson's disease (PD) brain. Attempts to decrease …
proteins and increased in post-mortem Parkinson's disease (PD) brain. Attempts to decrease …
LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
J Pei, NL Oliveira, SJ Recinto, A Kazanova… - bioRxiv, 2024 - biorxiv.org
Parkinson Disease (PD) is a progressive, neurodegenerative disorder characterised by
motor and non-motor symptoms. Emerging evidence suggests a link between PD and …
motor and non-motor symptoms. Emerging evidence suggests a link between PD and …
Adoptive transfer of mitochondrial antigen-specific CD8+ T-cells in mice causes parkinsonism and compromises the dopamine system
MN Elemeery, A Tchung, S Boulet, S Mukherjee… - bioRxiv, 2024 - biorxiv.org
The progressive dysfunction and degeneration of dopamine (DA) neurons of the ventral
midbrain is linked to the development of motor symptoms in Parkinson's disease (PD) …
midbrain is linked to the development of motor symptoms in Parkinson's disease (PD) …