The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis
and hormone release. In type 2 diabetes (T2D), along with decrements in plasma glucose …

Background. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower glycemia by
enhancing urinary glucose excretion. The physiologic response to pharmacologically …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Plasma free fatty acid (FFA) concentration is elevated in obesity, insulin resistance (IR), non-
alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and related comorbidities such …

The twin epidemic of obesity and diabetes is a major crisis globally. Several epidemiologic
studies reveal the parallel escalation of obesity and diabetes. The term 'diabesity'expresses …

Sodium-glucose cotransporter-2 (SGLT2) is selectively expressed in the human kidney,
where it executes reabsorption of filtered glucose with a high capacity; it may be overactive …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

The role of C17: 0 and C15: 0 in human health has recently been reinforced following a
number of important biological and nutritional observations. Historically, odd chain saturated …