Amputation injuries in mammals are typically non-regenerative; however, joint regeneration
is stimulated by BMP9 treatment, indicating the presence of latent articular chondrocyte …

It is long-established that innervation-dependent production of neurotrophic factors is
required for blastema formation and epimorphic regeneration of appendages in fish and …

Individuals with Down syndrome (DS), the result of trisomy of human chromosome Hsa21
(Ts21), present with an array of skeletal abnormalities typified by altered craniofacial …

ABSTRACT A mouse organoid culture model was developed to regenerate articular
cartilage by sequential treatment with BMP2 and BMP9 (or GDF2) that parallels induced …

Epimorphic regeneration is a multitissue regeneration process where amputation does not
lead to scarring, but blastema formation and patterned morphogenesis for which cell …

Complete extremity regeneration in mammals is restricted to distal amputations of the digit
tip, the terminal phalanx (P3). In mice, P3 regeneration is mediated via the formation of a …

Common to all types of injuries, inflammation is the initial stage of healing. The final outcome
of healing, however, can be quite distinct after different types of injuries. Some tissues, such …

Humans and mice have the ability to regenerate the distal digit tip, the terminal phalanx (P3)
in response to amputation. What distinguishes P3 regeneration from regenerative failure is …

Amputation of the mouse digit tip results in blastema‐mediated regeneration. In this model,
new bone regenerates de novo to lengthen the amputated stump bone, resulting in a …

Trisomy of human chromosome 21 (Ts21) individuals present with a spectrum of low bone
mineral density (BMD) that predisposes this vulnerable group to skeletal injuries. To …