Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Mesenchymal stem cells have been used for cardiovascular regenerative therapy for
decades. These cells have been established as one of the potential therapeutic agents …

Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

In recent years, various studies have increasingly explained platelet functions not only in
their central role as a regulator in cellular hemostasis and coagulation. In fact, there is …

The innate immune system is the first line of defense against invading pathogens or sterile
injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or …

Platelets are non-nucleated cells that play central roles in the processes of hemostasis,
innate immunity, and inflammation; however, several reports show that these distinct …

Neutrophil extracellular traps (NETs) comprise decondensed chromatin, histones and
neutrophil granular proteins and are involved in the response to infectious as well as non …

Besides mediating hemostatic functions, platelets are increasingly recognized as important
players of inflammation. Data from experiments in mice and men revealed various …

Central nervous system (CNS) injury is divided into brain injury and spinal cord injury and
remains the most common cause of morbidity and mortality worldwide. Previous reviews …

Although much has been made of the role of HMGB1 acting as an acute damage associated
molecular pattern (DAMP) molecule, prompting the response to tissue damage or injury, it is …