The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Non-kinase targets of protein kinase inhibitors
L Munoz - Nature Reviews Drug Discovery, 2017 - nature.com
Kinome-wide profiling platforms have comprehensively identified the relevant kinases that
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …
One Stone, Two Birds: High-Brightness Aggregation-Induced Emission Photosensitizers for Super-Resolution Imaging and Photodynamic Therapy
Z Wang, Y Zhou, Y Hao, Z Zhao, A Gao, H Ma… - Nano Letters, 2024 - ACS Publications
Most aggregation-induced emission (AIE) luminogens exhibit high brightness, excellent
photostability, and good biocompatibility, but these AIE-active agents, which kill two birds …
photostability, and good biocompatibility, but these AIE-active agents, which kill two birds …
Novel natural product-and privileged scaffold-based tubulin inhibitors targeting the colchicine binding site
M Dong, F Liu, H Zhou, S Zhai, B Yan - Molecules, 2016 - mdpi.com
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …
Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like …
The DYRK family contains kinases that are up-regulated in malignancy and control several
cancer hallmarks. To assess the anticancer potential of inhibitors targeting DYRK kinases …
cancer hallmarks. To assess the anticancer potential of inhibitors targeting DYRK kinases …
Synthesis, biological evaluation of novel thiopyrano [2, 3-d] thiazoles incorporating arylsulfonate moiety as potential inhibitors of tubulin polymerization, and molecular …
NH Metwally, MA Badawy, DS Okpy - Journal of Molecular Structure, 2022 - Elsevier
Abstract Novel series of thiopyrano [2, 3-d] 1, 3-thiazole derivatives incorporating
arylsulfonate moiety were synthesized and characterized by 1 H NMR, 13 C NMR, MS, and …
arylsulfonate moiety were synthesized and characterized by 1 H NMR, 13 C NMR, MS, and …
Microtubule depolymerization by kinase inhibitors: unexpected findings of dual inhibitors
K Tanabe - International Journal of Molecular Sciences, 2017 - mdpi.com
Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer.
However, some kinase inhibitors can also disrupt microtubule organization by directly …
However, some kinase inhibitors can also disrupt microtubule organization by directly …
Multi-targeting anticancer agents: Rational approaches, synthetic routes and structure activity relationship
We live in a world with complex diseases such as cancer which cannot be cured with one-
compound one-target based therapeutic paradigm. This could be due to the involvement of …
compound one-target based therapeutic paradigm. This could be due to the involvement of …
Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis
S Masaki, I Kii, Y Sumida, T Kato-Sumida… - Bioorganic & Medicinal …, 2015 - Elsevier
Dysregulation of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
has been demonstrated in several pathological conditions, including Alzheimer's disease …
has been demonstrated in several pathological conditions, including Alzheimer's disease …
DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing
Background The targeting of disease-related proteins is important for drug discovery, and
yet target-based discovery has not been fruitful. Contextualizing overall biological processes …
yet target-based discovery has not been fruitful. Contextualizing overall biological processes …