Photodynamic and photothermal therapies: synergy opportunities for nanomedicine

M Overchuk, RA Weersink, BC Wilson, G Zheng - ACS nano, 2023 - ACS Publications
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to
eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen …

Tumor targeting via EPR: Strategies to enhance patient responses

SK Golombek, JN May, B Theek, L Appold… - Advanced drug delivery …, 2018 - Elsevier
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …

Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours

Q Wang, Q Liang, J Dou, H Zhou, C Zeng, H Pan… - Nature …, 2024 - nature.com
An effective nanotherapeutic transport from the vasculature to the tumour is crucial for
cancer treatment with minimal side effects. Here we demonstrate that, in addition to the …

Clinical cancer nanomedicine

J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …

Cancer nanomedicine: progress, challenges and opportunities

J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …

Transport of drugs from blood vessels to tumour tissue

MW Dewhirst, TW Secomb - Nature Reviews Cancer, 2017 - nature.com
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …

Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …

S Kansız, YM Elçin - Advances in Colloid and Interface Science, 2023 - Elsevier
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

F Danhier - Journal of Controlled Release, 2016 - Elsevier
Tumor targeting by nanomedicine-based therapeutics has emerged as a promising
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …

Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?

Y Nakamura, A Mochida, PL Choyke… - Bioconjugate …, 2016 - ACS Publications
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …

Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …