Photodynamic and photothermal therapies: synergy opportunities for nanomedicine
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to
eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen …
eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen …
Tumor targeting via EPR: Strategies to enhance patient responses
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours
Q Wang, Q Liang, J Dou, H Zhou, C Zeng, H Pan… - Nature …, 2024 - nature.com
An effective nanotherapeutic transport from the vasculature to the tumour is crucial for
cancer treatment with minimal side effects. Here we demonstrate that, in addition to the …
cancer treatment with minimal side effects. Here we demonstrate that, in addition to the …
Clinical cancer nanomedicine
J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …
improved efficacy and safety. Although several nanotherapeutics have received clinical …
Cancer nanomedicine: progress, challenges and opportunities
J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …
application of various nanotechnologies for more effective and safer cancer treatment …
Transport of drugs from blood vessels to tumour tissue
MW Dewhirst, TW Secomb - Nature Reviews Cancer, 2017 - nature.com
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
F Danhier - Journal of Controlled Release, 2016 - Elsevier
Tumor targeting by nanomedicine-based therapeutics has emerged as a promising
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …
Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
Advances in nanomaterial-based targeted drug delivery systems
X Cheng, Q Xie, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …