Adequate blood supply is essential for tumor survival, growth and metastasis. The tumor
microenvironment (TME) is dynamic and complex, comprising cancer cells, cancer …

The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …

Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …

Vascular repair is considered a key restorative measure to improve long-term outcomes after
ischemic stroke. N 6-methyladenosine (m6A), the most prevalent internal modification in …

The molecular features of necroptosis in cardiac ischemia–reperfusion (IR) injury have been
extensively explored. However, there have been no studies investigating the physiological …

Cardiac ischemia–reperfusion (I/R) injury results mainly from mitochondrial dysfunction and
cardiomyocyte death. Mitophagy sustains mitochondrial function and exerts a pro-survival …

ABSTRACT Introduction: Hereditary Haemorrhagic Telangiectasia (HHT) is as an autosomal
dominant trait characterized by frequent nose bleeds, mucocutaneous telangiectases …

Pathogenesis of cardiac microvascular ischemia‐reperfusion (IR) injury is associated with
excessive mitochondrial fission. However, the upstream mediator of mitochondrial fission …

Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its
anti-proliferative and pro-apoptotic effects on several types of cancer have been well …

Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to
pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are …