A novel tool to eradicate an ancient scourge: the novel oral polio vaccine type 2 story

AS Bandyopadhyay, S Zipursky - The Lancet Infectious Diseases, 2023 - thelancet.com
The recent detection of vaccine-derived poliovirus (VDPV) in London (UK) and a case of
paralytic polio in New York (USA) have highlighted how the scourge of poliomyelitis has not …

Re‐emergence of poliovirus in the United States: Considerations and implications

GB Russo, T Goyal, K Tyler, KT Thakur - Annals of neurology, 2022 - Wiley Online Library
The first case of paralytic poliomyelitis in nearly a decade in the US was discovered in a 20‐
year‐old unvaccinated man from Rockland County, New York, in July 2022, who developed …

[HTML][HTML] Progress toward poliomyelitis eradication—worldwide, January 2021–March 2023

SE Lee - MMWR. Morbidity and mortality weekly report, 2023 - cdc.gov
In 2022, Malawi and Mozambique reported WPV1 cases linked to a Pakistan strain, the first
WPV1 cases in the African region since 2016. During 2022 and 2023, Afghanistan and …

[HTML][HTML] Genetic characterization of novel oral polio vaccine type 2 viruses during initial use phase under emergency use listing—worldwide, March–October 2021

J Martin - MMWR. Morbidity and Mortality Weekly Report, 2022 - cdc.gov
Discussion The most consequential risks known to be associated with use of live attenuated
Sabin OPVs include the emergence of VDPVs resulting from reversion to neurovirulence …

Assessment of serological responses following vaccination campaigns with type 2 novel oral polio vaccine: a population-based study in Tajikistan in 2021

A Mirzoev, GR Macklin, Y Zhang, BA Mainou… - The Lancet Global …, 2022 - thelancet.com
Background Novel oral poliovirus vaccine type 2 (nOPV2) was used to control an outbreak
of type 2 circulating vaccine derived poliovirus (cVDPV2) in Tajikistan, in 2021. We …

Oral polio vaccine stockpile modeling: insights from recent experience

KM Thompson, DA Kalkowska… - Expert Review of …, 2023 - Taylor & Francis
Background Achieving polio eradication requires ensuring the delivery of sufficient supplies
of the right vaccines to the right places at the right times. Despite large global markets …

Looking back at prospective modeling of outbreak response strategies for managing global type 2 oral poliovirus vaccine (OPV2) cessation

KM Thompson, DA Kalkowska… - Frontiers in Public …, 2023 - frontiersin.org
Introduction Detection of poliovirus transmission and ongoing oral poliovirus vaccine (OPV)
use continue to delay poliomyelitis eradication. In 2016, the Global Polio Eradication …

One billion doses and WHO prequalification of nOPV2: implications for the global polio situation and beyond

AS Bandyopadhyay, LV Cooper… - PLOS Global Public …, 2024 - journals.plos.org
With the COVID-19 pandemic abating, the only remaining Public Health Emergency of
International Concern is polio [1]. Remarkable progress has been made in reducing the …

Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences

DA Kalkowska, SGF Wassilak, E Wiesen… - Risk …, 2024 - Wiley Online Library
Due to the very low, but nonzero, paralysis risks associated with the use of oral poliovirus
vaccine (OPV), eradicating poliomyelitis requires ending all OPV use globally. The Global …

Worst‐case scenarios: Modeling uncontrolled type 2 polio transmission

DA Kalkowska, E Wiesen, SGF Wassilak… - Risk …, 2024 - Wiley Online Library
Abstract In May 2016, the Global Polio Eradication Initiative (GPEI) coordinated the
cessation of all use of type 2 oral poliovirus vaccine (OPV2), except for emergency outbreak …