An apparent quandary: adoption of polygenics and gene panels for personalised breast cancer risk stratification
JS Lanchbury, HJ Pederson - BJC Reports, 2023 - nature.com
Over the past 30 years, genetic and epidemiological advances have revolutionised the
prediction of breast cancer risk in women with significant family history. By screening these …
prediction of breast cancer risk in women with significant family history. By screening these …
[HTML][HTML] Revisiting HER2 in Prostate Cancer from an Inclusive Perspective: From Biomarkers to Omics
Simple Summary HER2 is a well-known driver of worse outcomes for many types of cancer,
including prostate cancer. While HER2 has been previously evaluated in prostate cancer …
including prostate cancer. While HER2 has been previously evaluated in prostate cancer …
Imputation of race and ethnicity categories using genetic ancestry from real-world genomic testing data
The incompleteness of race and ethnicity information in real-world data (RWD) hampers its
utility in promoting healthcare equity. This study introduces two methods—one heuristic and …
utility in promoting healthcare equity. This study introduces two methods—one heuristic and …
Validation of the RSClin risk calculator in the National Cancer Data Base
AGL Vannier, A Dhungana, F Zhao, N Chen… - Cancer, 2024 - Wiley Online Library
Background Guidelines recommend the use of genomic assays such as OncotypeDx to aid
in decisions regarding the use of chemotherapy for hormone receptor–positive, HER2 …
in decisions regarding the use of chemotherapy for hormone receptor–positive, HER2 …
West African Genetic Ancestry and Breast Cancer Outcomes Among Black Women
S Reid, R Fan, L Venton, A Weidner, A Tezak… - JAMA Network …, 2024 - jamanetwork.com
Importance Young Black women bear a disproportionate burden of breast cancer deaths
compared with White women, yet they remain underrepresented in genomic studies …
compared with White women, yet they remain underrepresented in genomic studies …
Association of genetic ancestry with molecular tumor profiles in colorectal cancer
Background There are known disparities in incidence and outcomes of colorectal cancer
(CRC) by race and ethnicity. Some of these disparities may be mediated by molecular …
(CRC) by race and ethnicity. Some of these disparities may be mediated by molecular …
The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer
G Ramshankar, R Liu, RJ Perry - Plos one, 2023 - journals.plos.org
L-type Amino Acid Transporter 1 (LAT1) facilitates the uptake of specific essential amino
acids, and due to this quality, it has been correlated to worse patient outcomes in various …
acids, and due to this quality, it has been correlated to worse patient outcomes in various …
A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors
Disparities in cancer diagnosis, treatment, and outcomes based on self-identified race and
ethnicity (SIRE) are well documented, yet these variables have historically been excluded …
ethnicity (SIRE) are well documented, yet these variables have historically been excluded …
Incorporating Real-World Clinico-Genomic Insights to Inform Diversity Enrollment Targets in Oncology Trials
The passage of the US Food and Drug Administration (FDA) Omnibus Reform Act of 2022
underscores a national commitment to enhancing diversity in clinical trials. This commitment …
underscores a national commitment to enhancing diversity in clinical trials. This commitment …
Disparities in Hormone Receptor-Positive Breast Cancer
ER Ogayo, EA Mittendorf, O Kantor - Current Breast Cancer Reports, 2024 - Springer
Abstract Purpose of Review While the incidence of hormone receptor-positive, HER2-
negative (HR+ HER2-) breast cancer is lower for Black women compared to White women …
negative (HR+ HER2-) breast cancer is lower for Black women compared to White women …