The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian
brain. Each isoform consists of five homologous or identical subunits surrounding a central …

Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal
systems. The most prominent players in neuronal inhibition are synaptic and extrasynaptic …

Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter
GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA …

Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

The GABAA receptor is the main inhibitory receptor in the brain and its subunits originate
from different genes or gene families (α1–α6, β1–β3, γ1–γ3, δ, ε, θ, π, or ρ1–3). In the mouse …

Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by
GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop …

GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to
tolerance development and abuse liability, their chronic use may cause cognitive …