Strategies for delivering therapeutics across the blood–brain barrier
GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
A historical review of brain drug delivery
WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …
[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
Near‐infrared‐light‐activatable nanomaterial‐mediated phototheranostic nanomedicines: an emerging paradigm for cancer treatment
R Vankayala, KC Hwang - Advanced Materials, 2018 - Wiley Online Library
Cancer is one of the most deadly diseases threatening the lives of humans. Although many
treatment methods have been developed to tackle cancer, each modality of cancer treatment …
treatment methods have been developed to tackle cancer, each modality of cancer treatment …
Microbubble agents: New directions
Microbubble ultrasound contrast agents have now been in use for several decades and their
safety and efficacy in a wide range of diagnostic applications have been well established …
safety and efficacy in a wide range of diagnostic applications have been well established …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Opening of the blood–brain barrier using low-intensity pulsed ultrasound enhances responses to immunotherapy in preclinical glioma models
A Sabbagh, K Beccaria, X Ling, A Marisetty, M Ott… - Clinical Cancer …, 2021 - AACR
Purpose: The blood–brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic
agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe …
agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe …
Ultrasound treatment of neurological diseases—current and emerging applications
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
Biomolecular ultrasound and sonogenetics
Visualizing and modulating molecular and cellular processes occurring deep within living
organisms is fundamental to our study of basic biology and disease. Currently, the most …
organisms is fundamental to our study of basic biology and disease. Currently, the most …