Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
[HTML][HTML] Primary motor cortex in Parkinson's disease: Functional changes and opportunities for neurostimulation
CF Underwood, LC Parr-Brownlie - Neurobiology of Disease, 2021 - Elsevier
Movement abnormalities of Parkinson's disease (PD) arise from disordered neural activity in
multiple interconnected brain structures. The planning and execution of movement requires …
multiple interconnected brain structures. The planning and execution of movement requires …
Values encoded in orbitofrontal cortex are causally related to economic choices
In the eighteenth century, Daniel Bernoulli, Adam Smith and Jeremy Bentham proposed that
economic choices rely on the computation and comparison of subjective values. This …
economic choices rely on the computation and comparison of subjective values. This …
Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation
Electrical stimulation is an effective tool for mapping and altering brain connectivity, with
applications ranging from treating pharmacology-resistant neurological disorders to …
applications ranging from treating pharmacology-resistant neurological disorders to …
Biophysically realistic neuron models for simulation of cortical stimulation
Objective. We implemented computational models of human and rat cortical neurons for
simulating the neural response to cortical stimulation with electromagnetic fields. Approach …
simulating the neural response to cortical stimulation with electromagnetic fields. Approach …
[HTML][HTML] Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation
Background Intracortical microstimulation (ICMS) is used to map neural circuits and restore
lost sensory modalities such as vision, hearing, and somatosensation. The spatial effects of …
lost sensory modalities such as vision, hearing, and somatosensation. The spatial effects of …
Orbitofrontal cortex contributes to the comparison of values underlying economic choices
Economic choices between goods entail the computation and comparison of subjective
values. Previous studies examined neuronal activity in the orbitofrontal cortex (OFC) of …
values. Previous studies examined neuronal activity in the orbitofrontal cortex (OFC) of …
The role of endogenous opioid neuropeptides in neurostimulation-driven analgesia
ST Lubejko, RD Graham, G Livrizzi… - Frontiers in Systems …, 2022 - frontiersin.org
Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain
management strategies. While opioid drugs have long been used to treat chronic pain, their …
management strategies. While opioid drugs have long been used to treat chronic pain, their …
In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of …
Electrical stimulation has been critical in the development of an understanding of brain
function and disease. Despite its widespread use and obvious clinical potential, the …
function and disease. Despite its widespread use and obvious clinical potential, the …
Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation
Objective. Neural prosthetics often use intracortical microstimulation (ICMS) for sensory
restoration. To restore natural and functional feedback, we must first understand how …
restoration. To restore natural and functional feedback, we must first understand how …