The X-linked gene encoding MECP2 is involved in two severe and complex
neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Parvalbumin-positive neurons are the largest class of GABAergic, inhibitory neurons in the
central nervous system. In the cortex, these fast-spiking cells provide feedforward and …

Sociability is crucial for survival, whereas social avoidance is a feature of disorders such as
Rett syndrome, which is caused by loss-of-function mutations in MECP2. To understand how …

Mutations in the X-linked gene MECP2 cause Rett syndrome, a progressive neurological
disorder in which children develop normally for the first one or two years of life before …

The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the
ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite …

Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by
serious pathophysiology, including breathing and feeding dysfunctions, and alteration of …

Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

Oxytocin receptors (OTRs) in the midbrain dorsal raphe (DR; the source of most forebrain
serotonin) have recently been identified as a potential pharmacological target for treating …