Highlights•Degraders are an emerging modality which fall into the 'beyond rule of
5'space.•Poor permeability and solubility are critical features limiting oral absorption.• …

Cyanobacteria and microalgae are oxygen-producing photosynthetic unicellular organisms
encompassing a great diversity of species, which are able to grow under all types of extreme …

Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Highlights•Seamless solubility understanding requires discovery-development
collaboration.•Gold standard methods in drug development map solubility of drug …

The exponential increase in our ability to harness multi-dimensional biological and clinical
data from experimental to real-world settings has transformed pharmaceutical research and …

Around 77 new oncology drugs were approved by the FDA in the past five years; however,
most cancers remain untreated. Small molecules and antibodies are dominant therapeutic …

According to the free drug hypothesis (FDH), only free, unbound drug is available to interact
with biological targets. This hypothesis is the fundamental principle that continues to explain …

Introduction We see a development in the field of long-acting products to serve patients with
chronic diseases by providing benefits in adherence, efficacy, and safety of the treatment …

While macrocyclic peptides are extensively researched for therapeutically relevant protein
targets, DNA-encoded chemical libraries (DELs) are developed at a quick pace to discover …

Diabetic retinopathy (DR) is a leading cause of irreversible blindness globally.
Qidengmingmu Capsule (QC) is a Chinese patent medicine used to treat DR, but the …