Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

L Lin, Y Dai, Y Xia - European Journal of Medicinal Chemistry, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

Continuous flow photochemistry for the preparation of bioactive molecules

M Di Filippo, C Bracken, M Baumann - Molecules, 2020 - mdpi.com
The last decade has witnessed a remarkable development towards improved and new
photochemical transformations in response to greener and more sustainable chemical …

Contribution of Knoevenagel condensation products toward the development of anticancer agents: An updated review

R Tokala, D Bora, N Shankaraiah - ChemMedChem, 2022 - Wiley Online Library
Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

The aryl hydrocarbon receptor (AhR) as a breast cancer drug target

JR Baker, JA Sakoff… - Medicinal research reviews, 2020 - Wiley Online Library
Breast cancer is the most common cancer in women, with more than 1.7 million diagnoses
worldwide per annum. Metastatic breast cancer remains incurable, and the presence of …

Pd-catalyzed tandem reaction of 2-aminostyryl nitriles with arylboronic acids: synthesis of 2-arylquinolines

T Xu, Y Shao, L Dai, S Yu, T Cheng… - The Journal of Organic …, 2019 - ACS Publications
A novel palladium-catalyzed protocol for the synthesis of 2-arylquinolines via tandem
reaction of 2-aminostyryl nitriles with arylboronic acids has been developed with good …

Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents

JR Baker, CC Russell, J Gilbert, A McCluskey… - RSC medicinal …, 2021 - pubs.rsc.org
We have identified specific dichlorophenylacrylonitriles as lead compounds in the
development of novel anticancer compounds, notably,(Z)-N-(4-(2-cyano-2-(3, 4 …

Modelling and Phenotypic Screening of NAP‐6 and 10‐Cl‐BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro

JR Baker, BL Pollard, AJS Lin, J Gilbert… - …, 2021 - Wiley Online Library
To exploit the interaction of the aryl hydrocarbon receptor (AhR) pathway in developing
breast‐cancer‐specific cytotoxic compounds, we examined the breast cancer selectivity and …

Next-generation of BBQ analogues that selectively target breast cancer

JR Baker, J Gilbert, NS O'Brien, CC Russell… - Frontiers in …, 2024 - frontiersin.org
We previously reported on the interaction of 10-chloro-7 H-benzo [de] benzo [4, 5] imidazo
[2, 1-a] isoquinolin-7-one (10-Cl-BBQ) with the Aryl hydrocarbon Receptor (AhR) and …

Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates

Y Jiang, B Wang, D Liu, D Xia, Z Liu, L Li… - Frontiers in …, 2022 - frontiersin.org
Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and
pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a …