Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
An insight into modern targeted genome-editing technologies with a special focus on CRISPR/Cas9 and its applications
Genome-editing technology has enabled scientists to make changes in model organisms'
DNA at the genomic level to get biotechnologically important products from them. Most …
DNA at the genomic level to get biotechnologically important products from them. Most …
CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections
FR van Diemen, EM Kruse, MJG Hooykaas… - PLoS …, 2016 - journals.plos.org
Herpesviruses infect the majority of the human population and can cause significant
morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes …
morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes …
Classifying PML risk with disease modifying therapies
JR Berger - Multiple sclerosis and related disorders, 2017 - Elsevier
Objective To catalogue the risk of PML with the currently available disease modifying
therapies (DMTs) for multiple sclerosis (MS). Background All DMTs perturb the immune …
therapies (DMTs) for multiple sclerosis (MS). Background All DMTs perturb the immune …
CRISPR-Cas biology and its application to infectious diseases
JR Strich, DS Chertow - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Infectious diseases remain a global threat contributing to excess morbidity and death
annually, with the persistent potential for destabilizing pandemics. Improved understanding …
annually, with the persistent potential for destabilizing pandemics. Improved understanding …
Inhibition of HSV-1 replication by gene editing strategy
PC Roehm, M Shekarabi, HS Wollebo, A Bellizzi… - Scientific reports, 2016 - nature.com
HSV-1 induced illness affects greater than 85% of adults worldwide with no permanent
curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for …
curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for …
Human genetic variation alters CRISPR-Cas9 on-and off-targeting specificity at therapeutically implicated loci
The CRISPR-Cas9 nuclease system holds enormous potential for therapeutic genome
editing of a wide spectrum of diseases. Large efforts have been made to further …
editing of a wide spectrum of diseases. Large efforts have been made to further …
CRISPR/Cas9-mediated noncoding RNA editing in human cancers
J Yang, X Meng, J Pan, N Jiang, C Zhou, Z Wu… - RNA biology, 2018 - Taylor & Francis
Cancer is characterized by multiple genetic and epigenetic alterations, including a higher
prevalence of mutations of oncogenes and/or tumor suppressors. Mounting evidences have …
prevalence of mutations of oncogenes and/or tumor suppressors. Mounting evidences have …
CRISPR/Cas9 landscape: Current state and future perspectives
M Tyumentseva, A Tyumentsev, V Akimkin - International Journal of …, 2023 - mdpi.com
CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is a unique
genome editing tool that can be easily used in a wide range of applications, including …
genome editing tool that can be easily used in a wide range of applications, including …
Antiviral goes viral: harnessing CRISPR/Cas9 to combat viruses in humans
JA Soppe, RJ Lebbink - Trends in microbiology, 2017 - cell.com
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune …
associated (Cas) systems are RNA-guided sequence-specific prokaryotic antiviral immune …