[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy

PK Datta, F Liu, T Fischer, J Rappaport, X Qin - Theranostics, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

[HTML][HTML] M1/M2 macrophages and their overlaps–myth or reality?

Z Strizova, I Benesova, R Bartolini… - Clinical …, 2023 - portlandpress.com
Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

[HTML][HTML] Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer

R Li, JR Ferdinand, KW Loudon, GS Bowyer, S Laidlaw… - Cancer Cell, 2022 - cell.com
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and
their multi-cellular interactions. To understand these dependencies within the wider …

Renal macrophages monitor and remove particles from urine to prevent tubule obstruction

J He, Y Cao, Q Zhu, X Wang, G Cheng, Q Wang, R He… - Immunity, 2024 - cell.com
When the filtrate of the glomerulus flows through the renal tubular system, various
microscopic sediment particles, including mineral crystals, are generated. Dislodging these …

[HTML][HTML] Resident macrophage subpopulations occupy distinct microenvironments in the kidney

MD Cheung, EN Erman, KH Moore, JMP Lever, Z Li… - JCI insight, 2022 - ncbi.nlm.nih.gov
The kidney contains a population of resident macrophages from birth that expands as it
grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages …

Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection

K Han, RV Blair, N Iwanaga, F Liu… - American journal of …, 2021 - atsjournals.org
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

[HTML][HTML] CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

Z Zhou, H Zhang, Y Tao, H Jie, J Zhao, J Zang, H Li… - Cell Reports, 2023 - cell.com
Adipose-derived stem cells (ASCs) drive healthy visceral adipose tissue (VAT) expansion
via adipocyte hyperplasia. Obesity induces ASC senescence that causes VAT dysfunction …

Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

E Conte - Pharmacology & Therapeutics, 2022 - Elsevier
Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Metabolic homeostasis of tissue macrophages across the lifespan

SK Wculek, S Forisch, V Miguel, D Sancho - Trends in Endocrinology & …, 2024 - cell.com
Macrophages are present in almost all organs. Apart from being immune sentinels, tissue-
resident macrophages (TRMs) have organ-specific functions that require a specialized …

[HTML][HTML] Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

N Richoz, ZK Tuong, KW Loudon, E Patiño-Martínez… - JCI insight, 2022 - ncbi.nlm.nih.gov
Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG
immune complex (IC) deposition in kidneys, with limited treatment options. Kidney …