Understanding AL amyloidosis with a little help from in vivo models
G Martinez-Rivas, S Bender, C Sirac - Frontiers in Immunology, 2022 - frontiersin.org
Monoclonal immunoglobulin (Ig) light chain amyloidosis (AL) is a rare but severe disease
that may occur when a B or plasma cell clone secretes an excess of free Ig light chains …
that may occur when a B or plasma cell clone secretes an excess of free Ig light chains …
Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe
L Del Pozo-Yauner, GA Herrera… - Frontiers in …, 2023 - frontiersin.org
The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of
antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem …
antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem …
How I treat AL amyloidosis
G Palladini, G Merlini - Blood, The Journal of the American …, 2022 - ashpublications.org
The treatment of patients with systemic light chain (AL) amyloidosis is a challenge to
hematologists. Despite its generally small size, the underlying clone causes a rapidly …
hematologists. Despite its generally small size, the underlying clone causes a rapidly …
Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
Machine learning has been recently used to predict therapeutic antibody aggregation rates
and viscosity at high concentrations (150 mg/ml). These works focused on commercially …
and viscosity at high concentrations (150 mg/ml). These works focused on commercially …
Chemical signatures to identify the origin of solid ashes for efficient recycling using machine learning
Solid ashes constitute the world's leading environmental problem and their efficient
recycling requires specific origin information. Chemical signatures encode the …
recycling requires specific origin information. Chemical signatures encode the …
Identification of AL proteins from 10 λ-AL amyloidosis patients by mass spectrometry extracted from abdominal fat and heart tissue
J Baur, N Berghaus, S Schreiner, U Hegenbart… - Amyloid, 2023 - Taylor & Francis
Background Systemic AL amyloidosis arises from the misfolding of patient-specific
immunoglobulin light chains (LCs). Potential drivers of LC amyloid formation are mutational …
immunoglobulin light chains (LCs). Potential drivers of LC amyloid formation are mutational …
Single‐molecule real‐time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies
P Cascino, A Nevone, M Piscitelli… - American Journal of …, 2022 - Wiley Online Library
To the Editor: Each patient with a monoclonal gammopathy has a unique monoclonal (M)
protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B …
protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B …
Genetic pathogenesis of immunoglobulin light chain amyloidosis: basic characteristics and clinical applications
L Xu, Y Su - Experimental Hematology & Oncology, 2021 - Springer
Immunoglobulin light chain amyloidosis (AL) is an indolent plasma cell disorder
characterized by free immunoglobulin light chain (FLC) misfolding and amyloid fibril …
characterized by free immunoglobulin light chain (FLC) misfolding and amyloid fibril …
How Artificial Intelligence Can Enhance the Diagnosis of Cardiac Amyloidosis: A Review of Recent Advances and Challenges
Cardiac amyloidosis (CA) is an underdiagnosed form of infiltrative cardiomyopathy caused
by abnormal amyloid fibrils deposited extracellularly in the myocardium and cardiac …
by abnormal amyloid fibrils deposited extracellularly in the myocardium and cardiac …
AB-Amy: machine learning aided amyloidogenic risk prediction of therapeutic antibody light chains
Y Zhou, Z Huang, Y Gou, S Liu, W Yang… - Antibody …, 2023 - academic.oup.com
Over 120 FDA-approved antibody-based therapeutics are used to treat a variety of diseases.
However, many candidates could fail because of unfavorable physicochemical properties …
However, many candidates could fail because of unfavorable physicochemical properties …